If you suffer from plaque psoriasis, you know the drill all too well—the redness, the itchiness, the unpredictability. Then there's the matter of treatment. You may have tried lotions, prescription shampoos, and every kind of cream and ointment—but may not be getting the results you're looking for.

If your current treatment is no longer working for you, it may be time to talk to your doctor about a different approach. Otezla® (apremilast) is a pill for moderate to severe plaque psoriasis—not an injection or a cream.

Watch this video for Otezla® (apremilast) stories from people who've been there

In the video below are Eddie, Sarah, and Elicia: 3 people who've all tried other treatments but have settled on Otezla to treat their plaque psoriasis. Individual results may vary.

Here are some things to know about Otezla:

It's a pill that can help you get clearer skin
In clinical studies, some people taking Otezla experienced 75% clearer skin, with reduced redness, thickness, and scaliness of plaques after just 4 months of treatment.

The most common side effects of Otezla were diarrhea, nausea, upper respiratory tract infection, tension headache, and headache.

Otezla has proven results for moderate to severe scalp psoriasis
In a clinical trial, 201 people taking Otezla were compared to 102 people taking a placebo (sugar pill).

43.3% of people taking Otezla saw an improvement in their scalp psoriasis after just 4 months of treatment, as compared to 13.7% taking placebo.

Some people also experienced a reduction in scalp and whole body itch after just 4 months of treatment.

The most common side effects of Otezla that occurred in the scalp psoriasis study were diarrhea, nausea, headache, and vomiting.

See below for additional Important Safety Information.

before and after images for otzela


Otezla® (apremilast) is a prescription medicine approved for the treatment of adult patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.


Do not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression and suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

© 2020 Amgen Inc. All rights reserved.
07/20 US-OTZ-20-0648

WebMD does not endorse any specific product, service, or treatment.

From WebMD

More on Psoriasis